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Epstein-Barr virus (EBV) oriP and the EBV nuclear antigen 1 (EBNA-1) protein allow persistence of EBV-based episomes. A nuclear matrix attachment region (MAR) spans oriP and the adjacent region of the EBV genome containing the EBV-expressed RNAs. Here, we show that episomes with the MAR are retained significantly more efficiently in EBV-positive B cells than episomes containing oriP alone.

Original publication

DOI

10.1128/JVI.75.22.11249-11252.2001

Type

Journal article

Journal

J Virol

Publication Date

11/2001

Volume

75

Pages

11249 - 11252

Keywords

Attachment Sites, Microbiological, B-Lymphocytes, Genes, Viral, Herpesvirus 4, Human, Humans, Nuclear Matrix, Plasmids, RNA, Viral, Replication Origin, Tumor Cells, Cultured