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Donald Hebb postulated the existence of a mechanism of activity-dependent transcription and synaptic modification almost 60 years ago. While the details of this process are still unclear, a new study by Ince-Dunn et al. in this issue of Neuron indicates that NeuroD2, a calcium-regulated transcription factor, plays a central role in thalamocortical synaptic maturation.

Original publication

DOI

10.1016/j.neuron.2006.02.012

Type

Journal article

Journal

Neuron

Publication Date

02/03/2006

Volume

49

Pages

639 - 642

Keywords

Animals, Basic Helix-Loop-Helix Transcription Factors, Calcium, Mice, Models, Biological, Neural Pathways, Neuropeptides, Somatosensory Cortex, Thalamus