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Intrinsic genetic differences and extrinsic influences both contribute to the formation of functional and anatomical areas within the mammalian cerebral cortex. Using subtractive hybridisation and differential screening, we demonstrated that plasticity-related gene-3 (PRG-3) is differentially expressed between the dorsal and lateral cortex at P6. PRG-3 is one of the key enzymes that are involved in the metabolism of phospholipids, such as LPA and S1P, in the nervous system. Here, for the first time, we report the mRNA expression pattern of PRG-3 in the developing and adult mouse cerebral cortex.

Original publication

DOI

10.1016/j.brainresbull.2005.05.010

Type

Journal article

Journal

Brain Res Bull

Publication Date

15/09/2005

Volume

66

Pages

454 - 460

Keywords

Age Factors, Animals, Animals, Newborn, Blotting, Southern, Cerebral Cortex, Cloning, Molecular, Embryo, Mammalian, Eosinophil Major Basic Protein, Gene Expression, Gene Expression Regulation, Developmental, In Situ Hybridization, Mice, Mice, Inbred C57BL, RNA, Messenger