Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Reward-seeking behaviors depend critically on dopamine signaling--dopamine neurons encode reward-related information by switching from tonic to phasic (burst-like) activity. Using guinea pig brain slices, we show that nicotine, like cocaine and amphetamine, acts directly in striatum where it enhances dopamine release during phasic but not tonic activity. This amplification provides a mechanism for nicotine facilitation of reward-related dopamine signals, including responses to other primary reinforcers that govern nicotine dependence in smokers.

Original publication

DOI

10.1038/nn1244

Type

Journal article

Journal

Nat Neurosci

Publication Date

06/2004

Volume

7

Pages

583 - 584

Keywords

Action Potentials, Animals, Corpus Striatum, Dopamine, Guinea Pigs, In Vitro Techniques, Nicotine, Reward