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This study hypothesized that dorsal root ganglion (DRG) stimulation would reduce sympathetic nerve activity and would alter hemodynamic variables. This study directly recorded muscle sympathetic nerve activity during ON and OFF stimulation of the DRG while measuring hemodynamic parameters. DRG stimulation significantly reduced the firing frequency of sympathetic nerves, as well as significantly reducing blood pressure, with greater reductions evident when stimulation was left-sided. Left-sided DRG stimulation lowers sympathetic nerve activity, leading to long-term phenotypic changes. This raises the potential of DRG stimulation being used to treat de novo autonomic disorders such as hypertension or heart failure.

Original publication

DOI

10.1016/j.jacbts.2020.07.010

Type

Journal article

Journal

JACC Basic Transl Sci

Publication Date

10/2020

Volume

5

Pages

973 - 985

Keywords

BF, burst frequency, BI, burst incidence, BP, blood pressure, DBP, diastolic blood pressure, DRG stimulation, DRG, dorsal root ganglion, DRGS, dorsal root ganglion stimulation, HR, heart rate, MAP, mean arterial pressure, MME, morphine milligram equivalent, MRBA%, median relative burst amplitude, MSNA, muscle sympathetic nerve activity, SBP, systolic blood pressure, SCS, spinal cord stimulation, VAS, visual analogue score of pain, blood pressure, hypertension, neuromodulation, sympathetic nerve activity