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Modulation of the mesocorticolimbic dopamine system by nicotinic acetylcholine receptors (nAChRs) is thought to play an important role in both health and addiction. However, a clear understanding of how these receptors regulate in vivo firing activity has been elusive. In this issue of Neuron, Mameli-Engvall and colleagues report an impressive and thought-provoking series of in vivo experiments combining single-unit recordings from dopamine neurons with nAChR subunit deletions and region-specific lentiviral subunit re-expression.

Original publication

DOI

10.1016/j.neuron.2006.05.024

Type

Journal article

Journal

Neuron

Publication Date

15/06/2006

Volume

50

Pages

815 - 816

Keywords

Action Potentials, Animals, Dopamine, Humans, Neurons, Receptors, Nicotinic