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Cardiac muscle creation during embryogenesis requires extracellular instructive signals that are regulated precisely in time and space, intersecting with intracellular genetic programs that confer or fashion the ability of the cells to respond. Unmasking the essential signals for cardiac lineage decisions has paramount importance for cardiac development and regenerative medicine, including the directed differentiation of progenitor and stem cells to a cardiac muscle fate.

Original publication

DOI

10.1161/CIRCRESAHA.110.223792

Type

Journal article

Journal

Circ Res

Publication Date

07/01/2011

Volume

108

Pages

129 - 152

Keywords

Animals, Cell Differentiation, Humans, Intercellular Signaling Peptides and Proteins, Myocardium, Signal Transduction, Stem Cells