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Visual guidance at the cellular level during neurosurgical procedures is essential for complete tumour resection. We present a compact reflectance confocal microscope with a 20 mm working distance that provided <1.2 μm spatial resolution over a 600 μm × 600 μm field of view in the near-infrared region. A physical footprint of 200 mm × 550 mm was achieved using only standard off-the-shelf components. Theoretical performance of the optical design was first evaluated via commercial Zemax software. Then three specimens from rodents: fixed brain, frozen calvaria and live hippocampal slices, were used to experimentally assess system capability and robustness. Results show great potential for the proposed system to be translated into use as a next generation label-free and contactless neurosurgical microscope.

Original publication

DOI

10.1364/boe.397832

Type

Journal article

Journal

Biomedical Optics Express

Publisher

The Optical Society

Publication Date

29/07/2020

Volume

11

Pages

4772 - 4785

Total pages

14

Keywords

reflectance confocal microscopy, contactless, neurosurgery