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Cardiac metabolism and function are intrinsically linked. High-energy phosphates occupy a central and obligate position in cardiac metabolism, coupling oxygen and substrate fuel delivery to the myocardium with external work. This insight underlies the widespread clinical use of ischaemia testing. However, other deficits in high-energy phosphate metabolism (not secondary to supply-demand mismatch of oxygen and substrate fuels) may also be documented, and are of particular interest when found in the context of structural heart disease. This review introduces the scope of deficits in high-energy phosphate metabolism that may be observed in the myocardium, how to assess for them, and how they might be interpreted.

Original publication

DOI

10.21037/cdt-20-275

Type

Journal article

Journal

Cardiovasc Diagn Ther

Publication Date

06/2020

Volume

10

Pages

625 - 635

Keywords

Energetics, cardiac magnetic resonance (CMR), magnetic resonance spectroscopy