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A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-kappaB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-kappaB activation is through inhibition of its translocation from the cytoplasm to the nucleus.

Original publication

DOI

10.1016/j.bmcl.2007.01.088

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

01/11/2007

Volume

17

Pages

6031 - 6035

Keywords

HeLa Cells, Humans, NF-kappa B, Thalidomide