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Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. In addition, the characteristic increase in taurine associated with dystrophic tissue is correlated with proteins associated with oxidative phosphorylation and mitochondrial metabolism.

Original publication

DOI

10.1021/pr800070p

Type

Journal article

Journal

J Proteome Res

Publication Date

05/2008

Volume

7

Pages

2069 - 2077

Keywords

Aging, Animals, Dystrophin, Male, Metabolism, Mice, Mice, Inbred C57BL, Mice, Inbred mdx, Muscular Dystrophy, Duchenne, Myocardium, Nuclear Magnetic Resonance, Biomolecular, Pattern Recognition, Automated, Proteome, Proteomics, Taurine