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Thousands of genes are involved in the regulation of our day-to-day metabolism and relatively little is understood about their function. One key protein, an ABC Transporter called ABCC5, has recently been predicted to be a susceptibility gene for Type 2 diabetes. In a new study selected as Editor's Choice in Obesity, Associate Professor Heidi de Wet has confirmed ABCC5's role in energy metabolism and identified the mechanism behind its metabolic impact for the first time.
Injected extracellular vesicles and other nanoparticles hitchhike on erythrocytes and platelets from circulation towards organ clearance
Journal article
Pavlova S. et al, (2026), Extracellular Vesicle, 7
The Impact of Polyethylene Glycol Lipid Anchors on the Physicochemical Properties, Protein Corona, Function, and Biodistribution of Lipid Nanoparticles.
Journal article
Lu C-E. et al, (2026), ACS Nano
N,N-diisopropyltryptamine and diptogenia: proposed mechanisms for a frequency-selective pitch-distorting psychedelic
Journal article
BAJO LORENZANA V. and Hurst A., (2026), Brain Communications
Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading
Preprint
Cramb KML. et al, (2026)
The scaling behavior of hippocampal activity in sleep/rest predicts spatial memory performance
Preprint
Živadinović P. et al, (2026)
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal article
De Coster W. et al, (2026), Nat Genet
Electromechanical modelling and simulation of human-induced pluripotent stem cell-derived cardiomyocytes predict drug-induced contractility effects.
Journal article
Folkmanaite M. et al, (2026), J Physiol
Determining the optimal management of geriatric type II odontoid fractures: a comparative network meta-analysis.
Journal article
Patel S. et al, (2026), Neurosurg Rev, 49
The metabolic balancing act between fatty acid and glucose substrate use for optimal myocardial function: Key role for membrane substrate transporters.
Journal article
Glatz JFC. et al, (2026), Am J Physiol Heart Circ Physiol
Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction.
Journal article
Zhang K. et al, (2026), Science, 391
Granule cells reorient cortical manifolds to separate contexts but preserve their geometry
Preprint
Garcia-Garcia MG. et al, (2026)
Interstitial Cells and Arrhythmia.
Journal article
Rog-Zielinska EA. et al, (2026), Am J Physiol Cell Physiol
Harnessing Phase Separation for the Development of High-Performance Hydrogels.
Journal article
Shao Y. et al, (2026), Adv Sci (Weinh)
Robust Immunohistochemical Detection of α-Synuclein, Tau, and β-amyloid in Human Brain Tissue Archived for up to 78 Years
Preprint
Just MK. et al, (2026)
A comment on cohort structure in Chiari I malformation studies.
Journal article
Nischal SA. et al, (2026), Clin Neurol Neurosurg, 262
Relief with a catch: hemodilution in chronic mountain sickness sparks an erythropoietin surge.
Journal article
Villafuerte FC. and Swietach P., (2026), Blood Red Cells Iron, 2
Urinary carbonic anhydrase 1 excretion is a marker of hemolysis-triggering conditions suitable for point-of-care testing.
Journal article
Hulikova A. et al, (2026), Blood Glob Hematol, 2
Coronary Artery Disease Detection and Disposition in Aircrew.
Journal article
Gray G. et al, (2026), Aerosp Med Hum Perform, 97, 210 - 217
Storage under hypoxia improves the ability of red cells to release oxygen in ex vivo–perfused human kidneys
Journal article
Rabcuka J. et al, (2026), Blood Red Cells & Iron, 2, 100038 - 100038