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Thousands of genes are involved in the regulation of our day-to-day metabolism and relatively little is understood about their function. One key protein, an ABC Transporter called ABCC5, has recently been predicted to be a susceptibility gene for Type 2 diabetes. In a new study selected as Editor's Choice in Obesity, Associate Professor Heidi de Wet has confirmed ABCC5's role in energy metabolism and identified the mechanism behind its metabolic impact for the first time.
Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response
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Singh T. et al, (2026), Genes and Diseases, 13
Injected extracellular vesicles and other nanoparticles hitchhike on erythrocytes and platelets from circulation towards organ clearance
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Pavlova S. et al, (2026), Extracellular Vesicle, 7
Opioid-free vs. opioid-inclusive anaesthesia with or without regional anaesthesia for postoperative pain: a systematic review with network meta-analysis of randomised controlled trials.
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de Carvalho CC. et al, (2026), Anaesthesia, 81, 702 - 712
Bionano Interface Optimization for Rational Lateral Flow Assay Development.
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Sadler CJ. et al, (2026), ACS Nano
Combined middle meningeal artery embolisation and subdural evacuation port system drainage for chronic subdural haematoma: a systematic review, single-arm meta-analysis, meta-regression, and cost-benefit analysis.
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Nischal SA. et al, (2026), Clin Neurol Neurosurg, 264
Movements During Intended General Anesthesia and Psychologically Traumatic Accidental Awareness: Explanatory Role of the "Efference Copy Network".
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Pandit JJ., (2026), Anesth Analg, 142, 909 - 916
Impaired glucose tolerance and mild diabetes induce β-cell dysfunction in mice.
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Haythorne E. et al, (2026), Nat Commun
The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning.
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Zhang Y-F. et al, (2026), Nat Commun
Faster and More Robust CK Reaction Rate Estimation at 3T Using Acquisition-Weighted 31P Cardiac 1D-MRSI With Compartment-Based Reconstruction.
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Axford A. et al, (2026), Magn Reson Med
Nipping Fraud in the Bud? Challenges for Detecting and Managing Issues of Research Integrity Before Publication.
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Haney MF. et al, (2026), Anesth Analg
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.
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Walth-Hummel AA. et al, (2026), Nat Commun, 17
The Basal Ganglia Upside Down: Non-Canonical Direct and Indirect Pathways Emerging from Striosomes Modulate Dopamine Release and Motor Behavior.
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Rocha GS. et al, (2026), J Neurophysiol
Towards automated joint detection in sleep studies: bridging clinical insight and artificial intelligence.
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Dorier A. et al, (2026), Sleep
Assessing the Metabolic Activity of Whole Regenerating Zebrafish Ventricles Ex Vivo Using an Extracellular Flux Assay.
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Lekkos K. et al, (2026), J Vis Exp
Epigenetic biomarkers in neurodegenerative diseases: from molecular signatures to therapeutic targets.
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Washer SJ. et al, (2026), Trends Neurosci
Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.
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Nielsen L-K. et al, (2026), Mov Disord
Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration.
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Zhou Z. et al, (2026), Nat Genet
Pitch at the Cocktail Party: A Comparative Approach to Studying Selective Attention.
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Ward J. et al, (2026), Biology (Basel), 15
Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta-Cell Function.
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Lloyd M. et al, (2026), FASEB J, 40
Cluster-First Labelling: An Automated Pipeline for Segmentation and Morphological Clustering in Histology Whole Slide Images
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Ahmad MH. et al, (2026), arXiv