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DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.
Cerebral blood flow as a mechanistic framework across neurological disease
Journal article
Patel S. et al, (2026), Discover Neuroscience, 21
CreER activation transiently disrupts angiogenesis by reducing proliferation and promoting apoptosis in vascular endothelial cells
Journal article
Ioannou E. et al, (2026), Angiogenesis, 29
Minimally invasive versus open transforaminal lumbar interbody fusion for low grade lumbar spondylolisthesis: a systematic review and meta-analysis.
Journal article
Patel S. et al, (2026), Spine Deform
5-HT4 Receptor Ligand RS67333 Modulates Striatal Acetylcholine and Dopamine Release via the Inhibition of Acetylcholinesterase.
Journal article
Qiao Q. et al, (2026), ACS Chem Neurosci
Patient experiences of tissue donation and digital consent support in primary craniospinal tumour research.
Journal article
Mawhinney G. et al, (2026), Support Care Cancer, 34
Presynaptic SNAP25 supports maturation of hippocampal mossy fiber-CA3 synapses.
Journal article
Hayashi S. et al, (2026), iScience, 29
Multistage microrobots with pH-responsive release of platelet membrane-coated nanoparticles.
Journal article
Sun R. et al, (2026), Sci Adv, 12
Deletion of Snap25 disrupts glial remodeling in aging mouse brain.
Journal article
Vadisiute A. et al, (2026), iScience, 29
Varicose projection astrocytes: Conserved reactive cells in brain pathology
Journal article
Ciani C. et al, (2026), Science Advances, 12
Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons.
Journal article
Achiwa H. et al, (2026), J Anat
Beyond neurotoxicity: A new face of 6-hydroxydopamine in cancer immunity.
Journal article
Sarker G. and Domingos A., (2026), Neuron, 114, 2489 - 2491
The perineurium integrates leptin with its sympathetic outflow to protect against obesity.
Journal article
Sarker G. et al, (2026), Nat Metab
Dopamine replacement therapy modulates DDC, prolactin and AOC3 levels in Parkinson's disease.
Journal article
van Hillegondsberg L. et al, (2026), NPJ Parkinsons Dis
TopoMetry systematically learns and evaluates the latent geometry of single-cell data.
Preprint
Sidarta-Oliveira D. et al, (2026)
TopoMetry systematically learns and evaluates the latent geometry of single-cell data
Journal article
Sidarta-Oliveira D. et al, (2026), eLife, 13
A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.
Journal article
Lee-Reeves C. et al, (2026), ACS Biomater Sci Eng
BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.
Journal article
Shao B. et al, (2026), Small
Cardiac evaluation in the armed forces. A statement of the European Association of Preventive Cardiology of the ESC.
Journal article
Abela M. et al, (2026), Eur J Prev Cardiol
How physiology solves the gene-centric impasse.
Journal article
Noble D. and Bourret R., (2026), Exp Physiol