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A drink developed for soldiers to generate energy from ketones rather than carbs or fat allowed highly trained cyclists to add up to 400 meters of distance to their workouts, an Oxford-led study has reported in journal Cell Metabolism. The supplement, which will be commercially available within the year, works by temporarily switching the primary source of cellular energy from glucose or fat to ketones - molecules derived from fat that are known to be elevated in people consuming a low-carb, Atkins-like, diet.
Cerebral blood flow as a mechanistic framework across neurological disease
Journal article
Patel S. et al, (2026), Discover Neuroscience, 21
Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response
Journal article
Singh T. et al, (2026), Genes and Diseases, 13
Dissecting genotype-specific effects of disease-associated genetic variants
Journal article
Farrow SL. et al, (2026), Iscience, 29
Reactive astrocytes mediate toxicity in iPSC derived dopaminergic neurons.
Journal article
Ibarra-Aizpurua N. et al, (2026), NPJ Parkinsons Dis
Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates.
Journal article
Sourd C. et al, (2026), Mol Ther Adv, 34
The seminal proteome of a monandrous fly, Drosophila subobscura.
Journal article
Dean R. et al, (2026), Proc Biol Sci, 293
Hypoxia differentially affects coronary vessel formation during heart development.
Journal article
Payne S. et al, (2026), Cardiovasc Res
Evolution of the frontal aslant tract and implications for primate vocalization and human speech.
Journal article
Citro S. et al, (2026), Nat Commun
Organ-specific fibroblast dynamics revealed via an integrated experimental-computational framework
Preprint
Stewart CL. et al, (2026)
Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions.
Journal article
Beaumont S. et al, (2026), J Physiol
Mean Arterial Pressure Augmentation for Acute Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Neurological Recovery and Mortality.
Journal article
Kale KM. et al, (2026), Global Spine J
Diagnostic performance of machine learning models versus established risk stratification for intracranial aneurysm rupture: a systematic review and bivariate meta-analysis.
Journal article
Patel S. et al, (2026), J Neurol Neurosurg Psychiatry
The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories.
Journal article
Mendoza-Silva V. et al, (2026), J Anat
GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease.
Journal article
Gmelin D. et al, (2026), Nat Commun, 17
Sleep immediately after noise overexposure worsens tinnitus in mice
Preprint
Milinski L. et al, (2026)
Opposing intrinsic and synaptic plasticity mechanisms stabilize altered cortical networks during sleep deprivation
Preprint
Burman RJ. et al, (2026)
Nucleophagy removes cytotoxic trapped PARP1.
Journal article
Hoslett G. et al, (2026), Nat Cell Biol
Machine learning-driven cancer diagnostics with improved robustness and interpretability.
Journal article
Li P. and Liu Z., (2026), Chem Sci
A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe.
Journal article
Causse AA. et al, (2026), Neuron
Injected extracellular vesicles and other nanoparticles hitchhike on erythrocytes and platelets from circulation towards organ clearance
Journal article
Pavlova S. et al, (2026), Extracellular Vesicle, 7