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New collaborative research from the Mommersteeg Group and MRC WIMM researchers shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
Injected extracellular vesicles and other nanoparticles hitchhike on erythrocytes and platelets from circulation towards organ clearance
Journal article
Pavlova S. et al, (2026), Extracellular Vesicle, 7
Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta-Cell Function.
Journal article
Lloyd M. et al, (2026), FASEB J, 40
Era of Sugammadex: A Paradigm Shift in Airway Management.
Journal article
Hagberg CA. et al, (2026), Anesthesiology, 144, 978 - 997
Biological and Genetic Definitions of Sex Versus Gender Identity in Perioperative Research: Linguistic Controversies and Implications for Healthcare.
Journal article
Pandit JJ., (2026), Anesth Analg
Retraction Note: Multisensory learning binds neurons into a cross-modal memory engram.
Journal article
Okray Z. et al, (2026), Nature
Hypoxic regulation of chromatin and gene transcription.
Journal article
Kindrick JD. et al, (2026), Commun Biol
Image-guided optimization of regenerative graft attachment to the heart.
Journal article
Feng Z. et al, (2026), Biomaterials, 332
Distinct roles of cortical layer 5 subtypes in associative learning.
Journal article
Moberg S. et al, (2026), Nat Commun, 17
Malondialdehyde as a Predictor of Disease Severity and Cardiovascular Risk in Population with Metabolic Dysfunction-Associated Steatotic Liver Disease.
Journal article
Lugo R. et al, (2026), Metabolites, 16
The Impact of Polyethylene Glycol Lipid Anchors on the Physicochemical Properties, Protein Corona, Function, and Biodistribution of Lipid Nanoparticles.
Journal article
Lu C-E. et al, (2026), ACS Nano
N,N-diisopropyltryptamine and diptogenia: proposed mechanisms for a frequency-selective pitch-distorting psychedelic
Journal article
BAJO LORENZANA V. and Hurst A., (2026), Brain Communications
Stools and stool-derived extracellular vesicles from patients with Parkinson’s disease contain alpha-synuclein species with seeding capacity
Preprint
Civitelli L. et al, (2026)
Vibrotactile positional therapy for the treatment of positional obstructive sleep apnoea: a multicentre, randomised controlled trial.
Journal article
Kelly JL. et al, (2026), Thorax, 81, 370 - 379
The scaling behavior of hippocampal activity in sleep/rest predicts spatial memory performance
Preprint
Živadinović P. et al, (2026)
Dopamine release from Parkinson’s patient-derived neurons is disrupted due to impaired synaptic vesicle loading
Preprint
Cramb KML. et al, (2026)
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Journal article
De Coster W. et al, (2026), Nat Genet
Electromechanical modelling and simulation of human-induced pluripotent stem cell-derived cardiomyocytes predict drug-induced contractility effects.
Journal article
Folkmanaite M. et al, (2026), J Physiol
Determining the optimal management of geriatric type II odontoid fractures: a comparative network meta-analysis.
Journal article
Patel S. et al, (2026), Neurosurg Rev, 49
The metabolic balancing act between fatty acid and glucose substrate use for optimal myocardial function: Key role for membrane substrate transporters.
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Glatz JFC. et al, (2026), Am J Physiol Heart Circ Physiol