Interstitial Cells and Arrhythmia.
Rog-Zielinska EA., Grune J., Kessler T., Lother A., Kohl P.
The electrophysiological relevance of interstitial non-myocytes for cardiac electrophysiology arises from their abundant direct and indirect interactions with cardiac myocytes. This mini-review defines the interstitium, explores biophysical and biochemical mechanisms of interactions between interstitial components and cardiac myocytes, illustrates consequences of these interactions for heart rhythm, and identifies targets for further research in this area.