Beyond neurotoxicity: A new face of 6-hydroxydopamine in cancer immunity
Sarker G., Domingos A.
In this issue of Neuron , Yu et al. show that 6-hydroxydopamine (6-OHDA) suppresses tumor growth beyond its established sympathetic neurotoxic activity by inducing a macrophage-TH1 immune axis, uncovering an unexpected immunomodulatory role with potential therapeutic implications for breast cancer.