More than 100 years after the original descriptions of altitude adaptation, it is now clear that many of these responses are mediated by a specific isoform of the transcription factor hypoxia-inducible factor (HIF)-2α. Here, we review this work, including connectivity with the oxygen chemosensitive response itself and with paraganglioma, a tumor often affecting chemosensitive tissues.
Journal article
2025-09-01T00:00:00+00:00
40
HIF, carotid body, hypoxia, oxygen chemosensitivity, ventilation, Humans, Oxygen, Basic Helix-Loop-Helix Proteins, Animals, Paraganglioma, Hypoxia, Endothelial PAS Domain-Containing Protein 1