Postdoctoral Research Scientist
As a postdoctoral research scientist in Oxford Chinese Medicine Research Centre, my research is on the pharmacological mechanism of the anti-arrhythmic Chinese medicine Xin Su Ning (XSN) capsule in Dr. Yu-ling Ma’s group. Most of the anti-arrhythmic Chinese medicines (CM) are composed of multiple herbal ingredients, and the regulative mechanism of CM on the heart or cardiomyocyte should be rational and integrative, therefore, my research interests are electrophysiological and network pharmacological mechanism of CM.
We carried on our research on isolated cardiomyocytes and cell lines transfected with ion channels with patch clamp to reveal why XSN could prolonged the action potential duration (APD) and tried to describe the coordinated regulation among multiple ion channels to explain why XSN can be used to treat cardiac arrhythmia but without pro-arrhythmic effects.
In 2016 I obtained my Ph.D. from Tianjin University of Traditional Chinese Medicine in China, investigating the anti-arrhythmic mechanism of Wenxin Keli (WK, Chinese patented drug) under the supervision of Professor Yan Zhu. During my Ph.D. training period, I joined Dr. Yu-ling Ma’s group in the Department of Physiology, Anatomy & Genetics in 2016 as a visiting student, working on the prolongation effect on APD and the inhibition effect on peak sodium current by XSN and active components.
An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis.
Wang T. et al, (2017), Mol Biosyst, 13, 1018 - 1030
Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C
Tian X. et al, (2016), Biological & Pharmaceutical Bulletin, 39, 181 - 191
Simplified captopril analogues as NDM-1 inhibitors
Li N. et al, (2014), Bioorganic & Medicinal Chemistry Letters, 24, 386 - 389