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FRET imaging

Cytosolic and mitochondrial targeted FRET reporters

Stefania Monterisi

PhD


Postdoctoral Research Scientist

 

RESEARCH INTEREST

I am a cellular and molecular biologist with expertise in intracellular signalling. My current field of research is colorectal cancer and my project is focused on investigating the role of proton signalling in cancer cells, how  pH can modulate biological functions in different cancer cell lines and the role of the stroma in acid handling.

In my previous research I looked at the compartmentalisation of cAMP/PKA signalling in different cell models. In cardiac myocytes I investigated the role of phosphodiesterases (PDEs), the enzymes that degrade both cAMP and cGMP, in cardiac hypertrophy and heart failure. In particular I studied the effect of PDE2 on mitochondria morphology and cell survival.

In cystic fibrosis airway cells my interest was directed to the activation pathway of CFTR and its interactome.

My technical skills are: FRET and FRAP imaging, biochemistry- WB, molecular biology techniques -PCR, genotyping, cell death/cell viability assays, confocal IF, histology, and the generation of genetically modified mice as tool to understand the effect of protein knock out in vivo.

 

BIOGRAPHY AND EDUCATION 

I earned my Master degree in Biological Sciences from the University of Bari, Italy. I obtained my PhD in Molecular and Cellular Biotechnologies from the same University, after spending part of my doctoral training at the Venetian Institute of Molecular Medicine in Padova, Italy, working on the alteration of signal transduction in Cystic Fibrosis.

I then received a fellowship to work at Glasgow University, UK, to refine my skills in FRET imaging technique.

I moved to Oxford in 2012 for a post-doctoral position, joining the group of Prof. Manuela Zaccolo to work on cyclic nucleotides signalling in heart disease. 

From July 2017 I joined the group of Prof. Pawel Swietach to work on pH signalling in cancer, in collaboration with Prof. Bodmer at the WIMM.

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Key publications

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Recent publications

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