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FRET imaging

Cytosolic and mitochondrial targeted FRET reporters

Stefania Monterisi


Postdoctoral Research Scientist


I earned my Master degree in Biological Sciences from the University of Bari, Italy. I obtained my PhD in Molecular and Cellular Biotechnologies from the same University, after spending part of my doctoral training at the Venetian Institute of Molecular Medicine in Padova, Italy, working on the alteration of signal transduction in Cystic Fibrosis.

I then received a fellowship to work at Glasgow University, UK, to refine my skills in FRET imaging technique.

I moved to Oxford in 2012 for a post-doctoral position, joining the group of Prof. Manuela Zaccolo to work on cyclic nucleotides signalling in heart disease. 

From July 2017 I joined the group of Prof. Pawel Swietach to work on pH signalling in cancer.



My current research is focused on investigating the role of proton signalling in cancer and how different pH can modulate biological functions in  cancer cell lines.

In my previous research I looked at the compartmentalisation of cAMP/PKA signalling in different cell models.

In cardiac myocytes I investigated the role of Phosphodiesterase 2, an enzyme that degrades both cAMP and cGMP, and its potential effect in heart failure.

In cystic fibrosis airway cells my interest was directed to the activation pathway of CFTR and its interactome.

The main experimental approach of my research is the use of FRET-based reporters in intact living cells, which allow monitoring cellular events with high spatial and temporal resolution. The imaging is combined with biochemistry, molecular biology techniques, cell death/cell viability assays and the use of genetically modified mice as tool to understand the effect of protein knock out in vivo.

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