Dr Sofia Stenler
|Tel||(+44) 01865 272199|
Postdoctoral Research Scientist
I am a postdoctoral researcher in Professor Matthew Wood’s lab in the Department of Physiology, Anatomy and Genetics at the University of Oxford. I currently work with novel therapies for neuromuscular diseases such as Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atopy (SMA). One of my focus areas is exploring the novel CRISPR technique for gene editing, as well as for upregulation of gene expression, to alleviate the pathology of these diseases. Another focus is the possibility of targeting episomal effector proteins to regulate muscle regeneration.
I am originally from Sweden, where I did my PhD studies at the Karolinska Institute. There, I investigated the minicircle vector for nonviral gene transfer, with special focus on optimization and on delivery to muscle.
Characterization and Applications in Muscle of a Minicircle Vector for Nonviral Gene Therapy
STENLER SH., (2015)
Safety and efficacy of DNA vaccines: plasmids vs. minicircles.
STENLER SH. et al, (2014), Human Vaccines and Immunotherapeutics, 1306 - 1308
Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression.
Stenler S. et al, (2014), Mol Ther Nucleic Acids, 2
Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides.
Hammond SM. et al, (2014), Mol Ther Nucleic Acids, 3
Gene Transfer to Mouse Heart and Skeletal Muscles Using a Minicircle Expressing Human Vascular Endothelial Growth Factor
Stenler S. et al, (2009), Journal of Cardiovascular Pharmacology, 53, 18 - 23