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My connections

  • OPDC Oxford Parkinson's Disease Centre

Sarah Threlfell


Senior Research Associate

Research Summary

As an Oxford Parkinson's Disease Centre (OPDC) Senior Research Fellow, my research uses neurochemical techniques including fast-scan cyclic voltammetry and HPLC to investigate monoamine transmission in the novel rodent models of Parkinson’s disease in the OPDC. In parallel, I use optogenetic technology to light-activate genetically targeted populations of neurons to further our understanding of fundamental neuromodulatory mechanisms within the basal ganglia – a group of structures in the brain which become dysfunctional in Parkinson’s disease. I am currently developing this technology to study neuronal subpopulations so we might shed light on the mechanisms underlying selective vulnerability of certain subpopulations of dopamine neurons in Parkinson’s disease.

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Recent Publications

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