Senior Research Associate
As an Oxford Parkinson's Disease Centre (OPDC) Senior Research Fellow, my research uses neurochemical techniques including fast-scan cyclic voltammetry and HPLC with electrochemical detection to investigate monoamine transmission in rodent models of Parkinson’s disease.
I am particularly interested in understanding the biological mechanisms that underpin early changes to dopamine transmission in rodent models of Parkinson's disease. There is increasing evidence that dsyfunction in synaptic transmission is one of the earliest changes to occur prior to neurodegeneration in Parkinson's disease models. It is therefore tempting to speculate that this early synaptic dysfunction might contribute to subsequent neurodegeneration. Through increasing our understanding of the mechanisms underlying early synaptic dysfunction, we aim to design strategies that might offset these changes in transmission and test whether these interventions are indeed neuroprotective.
Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.
Kosillo P. et al, (2016), Cereb Cortex
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Sloan M. et al, (2016), Hum Mol Genet, 25, 951 - 963
Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.
Pristerà A. et al, (2015), Proc Natl Acad Sci U S A, 112, E4929 - E4938
Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
Padovan-Neto FE. et al, (2015), J Neurosci, 35, 5781 - 5791
COUPLING VOLTAMMETRY WITH OPTOGENETICS TO REVEAL AXONAL CONTROL OF DOPAMINE TRANSMISSION BY STRIATAL ACETYLCHOLINE
Kosillo P. et al, (2014), Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience - Volume 1 Fundamentals and Applications, 1, 201 - 223