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Senior Research Associate
As an Oxford Parkinson's Disease Centre (OPDC) Senior Research Fellow, my research uses neurochemical techniques including fast-scan cyclic voltammetry and HPLC to investigate monoamine transmission in the novel rodent models of Parkinson’s disease in the OPDC. In parallel, I use optogenetic technology to light-activate genetically targeted populations of neurons to further our understanding of fundamental neuromodulatory mechanisms within the basal ganglia – a group of structures in the brain which become dysfunctional in Parkinson’s disease. I am currently developing this technology to study neuronal subpopulations so we might shed light on the mechanisms underlying selective vulnerability of certain subpopulations of dopamine neurons in Parkinson’s disease.
Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.
Kosillo P. et al, (2016), Cereb Cortex
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Sloan M. et al, (2016), Hum Mol Genet, 25, 951 - 963
Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.
Pristerà A. et al, (2015), Proc Natl Acad Sci U S A, 112, E4929 - E4938
Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
Padovan-Neto FE. et al, (2015), J Neurosci, 35, 5781 - 5791
COUPLING VOLTAMMETRY WITH OPTOGENETICS TO REVEAL AXONAL CONTROL OF DOPAMINE TRANSMISSION BY STRIATAL ACETYLCHOLINE
Kosillo P. et al, (2014), Compendium of in Vivo Monitoring in Real-Time Molecular Neuroscience - Volume 1 Fundamentals and Applications, 1, 201 - 223