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Sarah Threlfell

DPhil


Senior Research Associate

As an Oxford Parkinson's Disease Centre (OPDC) Senior Research Fellow, my research uses neurochemical techniques including fast-scan cyclic voltammetry and HPLC with electrochemical detection to investigate monoamine transmission in rodent models of Parkinson’s disease. 

I am particularly interested in understanding the biological mechanisms that underpin early changes to dopamine transmission in rodent models of Parkinson's disease. There is increasing evidence that dsyfunction in synaptic transmission is one of the earliest changes to occur prior to neurodegeneration in Parkinson's disease models. It is therefore tempting to speculate that this early synaptic dysfunction might contribute to subsequent neurodegeneration. Through increasing our understanding of the mechanisms underlying early synaptic dysfunction, we aim to design strategies that might offset these changes in transmission and test whether these interventions are indeed neuroprotective.  

Recent publications

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