- El Andaloussi Group Research Group
Samir El Andaloussi
Early Career Research Fellow
I defended my PhD in 2008 at the Department of Neurochemistry, Stockholm University, Sweden. I continued working as a research fellow in the lab of Prof Langel for two years. In 2010, I moved to the Department of Laboratory Medicine and the lab of Prof Edvard Smith at Karolinska Institutet for postdoctoral studies. During 2011 and 2012, I worked as a postdoctoral fellow in Prof Matthew Wood´s lab at the Department of Physiology, Anatomy and Genetics, University of Oxford and partially at Karolinska Institutet. Since 2013 I am employed at University of Oxford as a departmental early career research fellow and part-time as assistant professor at Karolinska Institutet. My interest is in understanding the mechanism of antisense oligonucleotide (ON) uptake into cells and how the chemical properties of ONs affect cellular uptake and activity. Also, I am developing peptide- and exosome based delivery vehicles for macromolecular drug delivery.
Exosome-mediated delivery of siRNA in vitro and in vivo.
El-Andaloussi S. et al, (2012), Nat Protoc, 7, 2112 - 2126
Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.
Andaloussi SE. et al, (2011), Nucleic Acids Res, 39, 3972 - 3987
Extracellular vesicles: biology and emerging therapeutic opportunities.
EL Andaloussi S. et al, (2013), Nat Rev Drug Discov, 12, 347 - 357
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation.
Ezzat K. et al, (2011), Nucleic Acids Res, 39, 5284 - 5298
Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers.
Thompson AG. et al, (2016), Nat Rev Neurol, 12, 346 - 357
Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice.
Jalabert A. et al, (2016), Diabetologia, 59, 1049 - 1058
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine.
Fais S. et al, (2016), ACS Nano, 10, 3886 - 3899
Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER.
Heusermann W. et al, (2016), J Cell Biol, 213, 173 - 184
mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration.
Roberts TC. et al, (2016), Genom Data, 7, 88 - 89