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Poohrawind Sanitt

Visiting Student

I obtained my Bachelor degree in Forest Biological Sciences from Kasetsart University, Thailand in 2004.  I was interested in forestry because of my love of  nature and my time spent exploring the forests in the mountains. During my Bachelor’s degree, I undertook some courses in the Department of Genetics during which my enthusiasm for investigating cellular mechanisms grew. I decided to pursue a Master’s degree in Molecular Genetics and Genetic Engineering at Mahidol University and graduated in 2006. My Master’s thesis focused on the mechanism by which binary toxins from bacteria kill mosquito larvae using protein structure and interaction analysis (Sanitt et al., 2008).

In 2009, I joined a lab working on shrimp molecular biology. My work here focused on prevention of viral infection in shrimp using dsRNA targeting viral and endogenous genes via oral delivery (Sannit et al., 2014; Sannit et al., 2016).  This encouraged me to find out more about how dsRNAs internalize into shrimp cells and activate the siRNA pathway, which eventually leads to viral suppression.  I was awarded a Scholarship from the Office of the Higher Education Commission, Thailand to undertake a Ph.D in Molecular Genetics and Genetic Engineering at the Institute of Molecular Biosciences, Mahidol University in 2015.  My work has demonstrated that extracellular dsRNA, a signaling molecule resulting from cell damage or viral infection, may interact directly with cell-surface expressed ATP synthase beta subunit through the nucleotide binding site, prior to internalization into hepatopancreatic cells via receptor mediated-endocytosis (manuscript in prep).

My Ph.D. Scholarship provided me with the opportunity to undertake one year of research abroad. I decided to apply to the Goberdhan Lab, because I am very interested in extracellular vesicles and the idea that they may be involved in the spread of RNA interference. In the Goberdhan Lab, I am working with the group to investigate the links between the glutamine-sensing amino acid transporter PAT4, the cellular microenvironmental sensor mTORC1 and extracellular vesicle signaling in prostate cancer development.

Recent Publications

Targeted mutagenesis at charged residues in Bacillus sphaericus BinA toxin affects mosquito-larvicidal activity.

Sanitt P, Promdonkoy B, Boonserm P (2008), Curr Microbiol.57, 230-4

Protection of yellow head virus infection in shrimp by feeding of bacteria expressing dsRNAs.

Sanitt P, Attasart P, Panyim S (2014), J Biotechnol. 2014 Jun 10;179:26-31

Cholesterol-based cationic liposome increases dsRNA protection of yellow head virus infection in Penaeus vannamei.

Sanitt P, Apiratikul N, Niyomtham N, Yingyongnarongkul BE, Assavalapsakul W, Panyim S, Udomkit A (2016), J Biotechnol. 228, 95-102