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Peregrine Green

Postgraduate Student

I completed my undergraduate and clinical training in Medicine at Oxford, obtaining a 1st class degree for my BA in Infection and Immunity in 2006 and graduating with Distinction in 2009.  I obtained my membership of the Royal College of Physicians in 2012, and am currently a Specialty Registrar in Cardiology in Oxford, sub-specialising in Electrophysiology and Cardiac Devices. 

I have been awarded an MRC-DTP scholarship to undertake a DPhil in Physiology, Anatomy and Genetics, with Professors Neil Herring and Oliver Rider. Biventricular cardiac pacing (or cardiac resynchronisation therapy - CRT) is known to improve morbidity and mortality in patients with severe systolic heart failure with a broad left bundle branch block, although comorbidities such as Diabetes Mellitus are associated with worse outcome.

However, CRT improves cardiac performance beyond simple electrical correction of the QRS duration on the electrocardiogram, with subsequent reverse remodelling and improvement in left ventricular function occurring in up to two thirds of patients. How reverse remodelling changes the heart from an “engine out of fuel” to one performing more efficiently at a higher stroke work is the focus of my research.