Peregrine Green

Biventricular cardiac pacing (or cardiac resynchronisation therapy - CRT) is known to improve morbidity and mortality in patients with severe systolic heart failure with left bundle branch block, although co-morbidities such as Diabetes Mellitus are associated with worse outcome. However, CRT improves cardiac performance beyond simple electrical correction of the QRS duration on the electrocardiogram, with subsequent reverse remodelling and improvement in left ventricular function occurring in up to two thirds of patients.  Using magnetic resonance spectroscopy and invasive haemodynamic measures, I am studying cardiac metabolism and efficiency. How reverse remodelling changes the heart from an “engine out of fuel” to one performing more efficiently at a higher stroke work is the focus of my research.

I am a British Heart Foundation Clinical Research Training Fellow, completing my DPhil at Oxford. My time is split between the Department of Physiology, Anatomy and Genetics (DPAG) and the Oxford Centre for Clinical Magnetic Resonance Research (OCMR), and I am supervised by Professors Neil Herring and Oliver Rider.  I completed my undergraduate and clinical training in Medicine at Oxford (1st class honours BA 2006 and Distinction with Prize 2009).  I obtained my membership of the Royal College of Physicians in 2012 and am a Specialty Registrar in Cardiology in Oxford, sub-specialising in Electrophysiology and Cardiac Devices.