Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

Pauline Marie

PhD

Postdoctoral Research Scientist

  • Postdoctoral Research Scientist in Cell Biology, Genetics and Cancer Research using Drosophila Melanogaster

After completing a bachelor's degree in life sciences between Evry-Val-d'Essonne and Madrid, I entered at the University Pierre and Marie Curie in Paris for my Master's degree in molecular and cellular biology. I defended my Ph.D. in genetics in 2016 entitled "From egg to adult: molecular and functional study of piRNA-mediated repression during germline development in Drosophila melanogaster".

In metazoan germ cells, transposable element activity is repressed by small noncoding PIWI-associated RNAs (piRNAs). Numerous investigations in Drosophila have enlightened the mechanism of this repression in the adult germline. However, very little was known about piRNA-mediated repression during germline development. Nevertheless, to maintain the integrity of the genome, repression should occur throughout the lifespan of germ cells.
During my PhD, I studied the piRNA-mediated repression activity and mechanism in the female germline, from late embryonic to pupal primordial germ cells using the powerful model D. melanogaster. I observed the piRNA synthesis during these stages of development and show that production of telomeric piRNAs depends on Heterochromatin Protein 1a (HP1a).

I recently arrived at Oxford University and joined the Wilson group at DPAG. The team is focused on the development of a novel model for prostate and prostate cancer in flies. I will be part of the project studying extracellular vesicle secretion and endolysosomal trafficking in vivo.

False False