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Research groups

Paige Williams

FHS Student

My FHS project is titled 'Stimulating neurogenesis with small molecules in an Alzheimer’s and aging mouse model'. Adult neurogenesis occurs in two stem cell niches in adult mammalian brains: the adult subventricular zone (SVZ) adjacent to the lateral ventricles, and the dentate gyrus of the hippocampus. The Szele Laboratory have screened for and found small molecules that increase adult neurogenesis in vitro and in vivo, one of which is OXS-N1. OXS-N1 was administered to SAMP8 mice, a model of Alzheimer’s disease, and behavioural assays showed improvements in memory. My FHS project will assess whether these SAMP8 mice show a significant increase in markers of adult neurogenesis in the olfactory bulb, SVZ and hippocampus, compared to SAMP8 controls given PBS. I will generate tissue sections and carry out immunohistochemical labelling of NeuN, doublecortin and bromodeoxyuridine. Data will be collected on a confocal microscope and statistically evaluated.