Natalie Connor-Robson
Postdoctoral Career Development Fellow
Research Interests
As part of the Oxford Parkinson’s disease centre my research is based around characterising the earliest pathogenic changes that occur in Parkinson’s disease (PD) and trying to understand how this leads to disease. I am investigating how these molecular alterations lead to and cause the progression of the disease with the hope that this will allow us to develop a much better understanding of Parkinson’s.
My work uses genetic models of PD and I am particularly interested in how mutations in Glucocerebrosidase (GBA) and LRRK2 lead to PD.
Biography
I studied Biomedical Sciences at Cardiff University graduating in 2009 and going on to complete my PhD in 2013 at the same university. My PhD also concentrated on the mechanisms of Parkinson’s disease with particular interest in a loss of function role for alpha-synuclein.
Recent publications
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GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Journal article
Roberts BM. et al, (2020), Nat Commun, 11
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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease.
Journal article
Bengoa-Vergniory N. et al, (2020), Nat Commun, 11
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Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.
Journal article
Simanaviciute U. et al, (2020), J Neurosci Methods, 331
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"LRRK2: Autophagy and Lysosomal Activity".
Journal article
Madureira M. et al, (2020), Front Neurosci, 14
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Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism
Journal article
Roberts BM. et al, (2019)