Muhammad Mohd Kassim
Postgraduate DPhil Student
I graduated from Universiti Putra Malaysia with a BSc (Hons) Biochemistry in 2010 and subsequently was awarded an MSc in Molecular Biology in 2014. At Oxford, I have worked with Prof Ji-Long Liu in the MRC Functional Genomics Unit on a project building on work in his lab showing that the metabolic enzyme CTP synthase can be compartmentalised in to filamentous intracellular structures known as cytoophidia. In the Liu Lab I screened for further metabolic enzymes that could also be contained within these structures using the experimental model, Saccharomyces cerevisiae. Interestingly, this study revealed that many of the key metabolic enzymes involved in glucose, fatty acid, amino acid and even nucleotide metabolism can polymerise into cytoophidia when nutrients are scarce.
In 2015, I moved to the Goberdhan lab to study how the deregulation of the key growth control network involving PI3K and the microenvironmental stress sensor, mTORC1 is involved in promoting aspects of tumorigenic growth and metastasis. I am following up on work in the lab showing that several amino acid-sensing transporters can regulate mTORC1, and the finding that these signals may affect the secretion and functions of exosomes, extracellular vesicles initially formed within intracellular endosomal compartments. I will be able to use the strong translational links the group has developed to investigate the clinical relevance of my studies.
I am one of the recipients of The Khazanah-Oxford Centre for Islamic Studies Merdeka Scholarship.