I’m reading for my DPhil at Campion Hall, Oxford and joined the Goberdhan lab in October 2012. Having undertaken my Masters project at the gene therapy group in the Harbottle lab http://www.imperial.ac.uk/people/r.harbottle, Imperial College, London, I have developed my interest in cancer biology further by investigating nano-vesicle signalling.
The overarching question I’m investigating in Oxford is whether the activity of the microenvironmental sensor mTORC1 and the secretion of small vesicles, known as exosomes might be mechanistically linked. My current data strongly suggest that they are, and I have extended my studies to test the physiological consequences of these changes. We work closely with the Wilson lab, which has collaborated with us to develop a new fly exosome model that allows us to probe the genetic regulation of altered exosome signalling.
Corrigan, L, Redhai S, Leiblich A, Fan SJ, Perera SM, Patel R, Gandy C, Wainwright SM, Morris JF, Hamdy F, Goberdhan DCI*, Wilson C* (2014) BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior. J Cell Biol 206, 671-88.
*contributed equally to this paper
Perera MWS, Gunasinghe D, Perera PAJ, Ranasinghe A, Amaratunga P, Warnakulasuriya S, Kaluarachchi K. (2007) Development of an in vivo mouse model to study oral submucous fibrosis. J Oral Pathol Med 36, 273-80.
Awarded the runner-up prize for Peter Beaconsfield Prize (2014) in Physiological Sciences, Medical Division, University of Oxford.