|Tel||01865 285864, 01865 285881|
- Oliver Group Research Group
Postdoctoral Research Scientist
University of Oxford, 2007-2010, D.Phil. in Neurosciences (2010)
Imperial College, London, 2006-2007, M.Sc. in Biomedical Research (2007)
University of Biological Engineering, SupAgro, Montpellier, France, 2004-2007, M.Sc. in Bioengineering (2007)
My main research interest is to understand the cellular mechanisms involved in neurodegenerative disorders.
I completed my D.Phil. project in Prof Kay Davies' group where I dissected the mechanisms underlying death of specific neurons in two mouse models of movement disorders. In particular, I studied the novel mitochondrial oxidative resistance (Oxr1) gene and its role in neuronal survival and its protective effect against oxidative stress.
During my first postdoc at Mount Sinai School of Medicine in New York City in Dr Jenny Zou's laboratory (2011-2013), I used a translational approach to study another neurological condition: I developed and tested a possible therapeutic strategy to induce severed adult neurons to regenerate after a spinal cord injury.
For my second postdoc in Dr Peter Oliver's laboratory, I am investigating the function of a family of proteins related to Oxr1, all sharing a highly conserved TLDc domain.
I was recently awarded a Johnson & Johnson Innovation Junior Research Fellowship in Neuroscience related to Medicine from St Edmund Hall and the top Goodger and Schorstein Scholarship.
The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.
Parsons MJ. et al, (2015), Cell, 162, 607 - 621
Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.
Finelli MJ. et al, (2015), Hum Mol Genet, 24, 3529 - 3544
Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.
Liu KX. et al, (2015), Brain, 138, 1167 - 1181
Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.
Moore JM. et al, (2014), PLoS One, 9
Epigenetic regulation of sensory axon regeneration after spinal cord injury.
Finelli MJ. et al, (2013), J Neurosci, 33, 19664 - 19676
Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development.
Finelli MJ. et al, (2013), Cell Rep, 3, 1592 - 1606
The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy
Carroll B. et al, (2013), Developmental Cell, 25, 15 - 28
Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.
Oliver PL. et al, (2011), PLoS Genet, 7
AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development.
Bitoun E. et al, (2009), J Neurosci, 29, 15366 - 15374
Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.
Hall SE. et al, (2009), Mol Pharmacol, 75, 1325 - 1336