Research groups
Websites
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DPAG Postdoctoral Society
Committee Member
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DPAG Athena SWAN
Committee Member
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The Physiological Society
Oxford Representative
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UNIQ
Summer Schools
Mark Richards
PhD
Postdoctoral Research Scientist
Research Interest
ion control and signalling in cardiac hypertrophy and heart failure.
Throughout my academic career I have been fascinated by the way in which transport of simple ions can have complex functional consequences for excitable cells, and how this is perturbed in pathology.
The main focus of my work has been investigating the physiology and regulation of ion flux in cardiac cells. I am currently working on a BHF-funded Programme Grant investigating the role of intracellular pH regulation and its cross-talk with signalling cascades in stress-induced cardiac hypertrophy and heart failure.
My research has led me to employ functional and molecular/biochemical techniques: electrophysiological recordings including sharp microelecrode and patch-clamp, live cell fluorescence imaging, virally-transduced FRET imaging, confocal microscopy, immunofluorescence imaging, RT-PCR, SDS-PAGE/Western blotting, Phostag gel analysis. I have also used in vivo approaches such as conscious animal blood pressure and electrocardiography recording and surgical techniques including implantation of osmotic minipumps.
Crosstalk between cGMP and cAMP produces biphasic modulation of NHE1 by NO
Key publications
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Journal article
Richards MA. et al, (2020), Cardiovasc Res, 116, 1958 - 1971
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Journal article
Richards M. et al, (2016), Cardiovasc Res, 110, 395 - 407
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Journal article
Richards MA. et al, (2011), American Journal of Physiology-Heart and Circulatory Physiology, 301, H1996 - H2005
Recent publications
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Journal article
Richards MA. et al, (2020), Cardiovasc Res, 116, 1958 - 1971
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Journal article
Loonat AA. et al, (2019), J Mol Cell Cardiol, 130, 184 - 196
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Journal article
Ford KL. et al, (2017), Cardiovasc Res, 113, 984 - 995
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Journal article
Egom EE-A. et al, (2016), Mol Cell Biochem, 419, 83 - 92
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Journal article
Richards M. et al, (2016), Cardiovasc Res, 110, 395 - 407
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Journal article
Dibb KM. et al, (2013), Journal of Molecular and Cellular Cardiology, 58, 84 - 91
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Journal article
Richards MA. et al, (2011), American Journal of Physiology-Heart and Circulatory Physiology, 301, H1996 - H2005
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Journal article
Horn MA. et al, (2010), Biophysical Journal, 98, 719a - 719a
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Journal article
Dibb KM. et al, (2009), Circulation: Heart Failure, 2, 482 - 489