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Mark Richards

PhD


Postdoctoral Research Scientist

Research Interest

ion control and signalling in cardiac hypertrophy and heart failure.

Throughout my academic career I have been fascinated by the way in which transport of simple ions can have complex functional consequences for excitable cells, and how this is perturbed in pathology.

The main focus of my work has been investigating the physiology and regulation of ion flux in cardiac cells. I am currently working on a BHF-funded Programme Grant investigating the role of intracellular pH regulation and its cross-talk with signalling cascades in stress-induced cardiac hypertrophy and heart failure.

My research has led me to employ functional and molecular/biochemical techniques: electrophysiological recordings including sharp microelecrode and patch-clamp, live cell fluorescence imaging, virally-transduced FRET imaging, confocal microscopy, immunofluorescence imaging, RT-PCR, SDS-PAGE/Western blotting, Phostag gel analysis. I have also used in vivo approaches such as conscious animal blood pressure and electrocardiography recording and surgical techniques including implantation of osmotic minipumps.

Crosstalk between cGMP and cAMP produces biphasic modulation of NHE1 by NO

From Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1. 
Cardiovasc Res. 2020 Oct 1;116(12):1958-1971. DOI:10.1093/cvr/cvz311
From Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1. Cardiovasc Res. 2020 Oct 1;116(12):1958-1971. DOI:10.1093/cvr/cvz311

Key publications

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