Postdoctoral Research Scientist
- Novo Nordisk Postdoctoral Fellow
I started my Novo Nordisk Postdoctoral Research Fellowship in September 2018, working with Associate Professor Vladyslav Vyazovskiy and Dr James Cantley in the Department of Physiology, Anatomy and Genetics and Associate Professor Stuart Peirson in the Nuffield Department of Clinical Neurosciences. The aim of this project is to investigate the link between glucose homeostasis and fasting-induced torpor in mice. This project draws on my previous experience recording brain activity using complex electrophysiological techniques such as electroencephalography (EEG), and will also establish a new technique of continuous glucose monitoring (CGM), which allows for continuous recording of blood glucose, core body temperature and activity in mice. This is an exciting opportunity to investigate the physiological mechanisms and the potential metabolic costs associated with torpor.
I hold a BSc Medical Sciences (Industrial) degree from the University of Leeds, with a specialisation in neuroscience. My DPhil was in the laboratory of Associate Professor Vladyslav Vyazovskiy in the Department of Physiology, Anatomy and Genetics (DPAG) at the University of Oxford. The main aim of my DPhil was to characterise the cortical neural activity underlying the effects of ageing on sleep. In particular, I was interested in how properties of slow waves, the predominant brain oscillation occurring during non-rapid eye movement (NREM) sleep, are affected by ageing. Both my BSc and DPhil were in collaboration with the pharmaceutical company Eli Lilly, UK.
Sleep- and Wake-Like States in Small Networks In Vivo and In Vitro.
McKillop LE. and Vyazovskiy VV., (2019), Handb Exp Pharmacol, 253, 97 - 121
Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.
Ang G. et al, (2018), Transl Psychiatry, 8
Cortical region-specific sleep homeostasis in mice: effects of time of day and waking experience.
Guillaumin MCC. et al, (2018), Sleep, 41
Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.
McKillop LE. et al, (2018), J Neurosci, 38, 3911 - 3928
THE CORTICAL NEURAL ACTIVITY OF MICE IS RESILIENT TO AGEING, DESPITE MARKED DISRUPTION IN GLOBAL SLEEP
McKillop LE. et al, (2017), SLEEP MEDICINE, 40, E218 - E219