Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we will assume that you are happy to receive all cookies and you will not see this message again. Click 'Find out more' for information on how to change your cookie settings.

My connections

Katharina Wagner


Postgraduate Student

Research Summary

I am working on a project that brings together two cutting-edge transgenic mouse models developed in the Wade-Martins Laboratory. The Laboratory has generated a transgenic mouse line overexpressing human wild-type alpha-synuclein within a bacterial artificial chromosome (BAC). This model has been shown to recapitulate the sequence of pathological events seen in Parkinson's (Janezic, S et al. 2013). From a young age, these mice exhibit a reduced release of dopamine in the dorsal striatum, while old animals display an age-dependent loss of nigrostriatal dopaminergic neurons and motor impairments characteristic of Parkinson's.

In order to account for the deficiencies observed in these mice, I will carry out a comparative study of the translated mRNAs in dopaminergic neurons. This will be achieved by making use of a second transgenic mouse line that enables the profiling of translated mRNAs specifically in dopaminergic neurons (bacTRAP mice). By crossing both mouse lines, I will be able to analyse perturbations in translated gene expression in vulnerable and resistant dopaminergic neurons. By investigating translational changes occurring during Parkinson's disease in vivo, we hope to obtain a more complete understanding of the underlying pathological pathways.

False False