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Whole-cell patch clamp recordings

Recordings from single or synaptically coupled principal cells are performed to examine how the ongoing network state promotes synaptic plasticity.


Julian Bartram


Postdoctoral Research Scientist

MSc in Neuroscience (University of Oxford), BSc in Molecular and Cellular Biology (University of Heidelberg)

I am currently a graduate student in the final phase of the Wellcome Trust OXION DPhil Programme. My research project in the Mann group attempts to shed some light on, perhaps, one of the most unexplored areas in neuroscience: the functions of sleep.

Sleep is a behavioural state or process that is evidently needed for normal cognitive performance and health. Indeed, there is now considerable evidence that particularly deep sleep, with characteristic cortical slow-wave activity, mediates some important aspects of learning and memory such as memory consolidation and integration. In the light of this, it is surprising how little we know about the specific rules of synaptic plasticity associated with characteristic activity patterns of sleep.

In my DPhil project, we therefore seek to elucidate the rules and cellular and circuit mechanisms governing synaptic plasticity during cortical slow-wave activity. This is being addressed with a variety of electrophysiological techniques. Moreover, in collaboration with Dr Simon Tuohy and Professor Toni Wilson’s group (Engineering), advanced imaging systems including two-photon microscopy with remote focusing are being employed. Some of these approaches are further illustrated on this website.

 

Recent Publications

Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model.

Wright S. et al, (2015), Brain, 138, 3159 - 3167


Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover.

Bright DP. et al, (2011), J Neurosci, 31, 753 - 763

High-resolution two-photon imaging allows a detailed morphological characterisation of neurons and the localisation of putative synapses between coupled cells. Furthermore, fast laser scanning in all three dimensions using the remote focusing technology allows simultaneous imaging of neural activity in long dendritic sections (see green segment).