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My connections

Jie Yin


Postgraduate Student

Biography

biography

I got my BSc degree in pharmacology in Southwest University where I worked on nerve regeneration after spinal cord injury. Then I read for MSc degree in molecular neurobiology at the Institute of Biophysics, Chinese Academy of Sciences. My project was about regulating microglial activation following acute cerebral ischemia-reperfusion injury. I also investigated the intracellular trafficking process of TREM2 in microglia, which plays an important role in the development of Alzheimer’s disease. In October 2016, I joined Francis Szele’s group as a PhD student. Here I am working on the potential function of dysbindin-1 in microglia.

research interests

I am interested in microglia-mediated neuroinflammation in the development of neurodegenerative diseases and psychiatric disorders. Neuroinflammation is considered to execute both detrimental and beneficial effects on neurons. Microglia appears to have diverse functional phenotypes that range from pro-inflammatory M1 phenotypes to immunosuppressive M2 phenotypes, which function differently in the initiation and resolution periods of immune responses. In order to keep tissue homeostasis, microglial activation must be fine-regulated. I am particularly interested in how the two phenotypes could be transited into each other in different pathological context.