- Ashcroft Group Research Group
Jeroen De Baaij
Jeroen de Baaij studied Medical Biology at the Radboud University Nijmegen from 2005-2008. From 2008-2010 he enrolled in the Master of Integrative Biology with specialization Physiology and pathophysiology at the Université Pierre et Marie Curie in Paris, France. Subsequently, he started as PhD Student at the department of Physiology, Radboud university medical center, Nijmegen, in 2010. Under the supervision of Prof. Dr. Joost G.J. Hoenderop and Prof. Dr. René J.M. Bindels, he focused on new genes involved in the regulation of magnesium transport in the kidney. After obtaining his PhD degree, Jeroen was awarded a Rubicon grant which allowed him to join the department as post doctoral researcher. Jeroen’s current work focusses on the role of magnesium in the development of type 2 diabetes mellitus in the group of Prof. dr. Frances Ashcroft.
Hypomagnesaemia (serum magnesium (Mg2+) <0.7 mmol/L) has been strongly associated with type 2 Diabetes Mellitus (T2DM). Patients with reduced serum Mg2+ concentrations show a more rapid disease progression. Moreover, dietary Mg2+ supplementation for patients with T2DM improves glucose metabolism and insulin sensitivity. However, the molecular mechanism by which Mg2+ improves T2DM has not been elucidated yet.
As postdoctoral researcher at the Department of Physiology, Anatomy and Genetics of the University of Oxford, I aim to understand the molecular mechanisms by which Mg2+ slows down the progression of T2DM. Our studies propose that hypomagnesaemia contributes to the pathogenesis of T2DM.
Magnesium in man: implications for health and disease.
de Baaij JH. et al, (2015), Physiol Rev, 95, 1 - 46
Genetic causes of hypomagnesemia, a clinical overview.
Viering DHHM. et al, (2017), Pediatr Nephrol, 32, 1123 - 1135
Identification of SLC41A3 as a novel player in magnesium homeostasis.
de Baaij JH. et al, (2016), Sci Rep, 6
Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia.
Hess MW. et al, (2016), Aliment Pharmacol Ther, 43, 1178 - 1185
Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth.
Kostantin E. et al, (2016), J Biol Chem, 291, 10716 - 10725
Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling.
Blanchard MG. et al, (2016), J Am Soc Nephrol, 27, 804 - 813