|Tel||01865 285830, 01865 285814|
Wellcome Trust Oxion Proteomics Core Facilities Scientist
I am interested in the application of proteomics, chemical biology and mass spectrometry to the investigation of cell physiology. In particular my research interests focus on cellular ubiquitination and other regulatory post-translational modifications. This includes detailed characterisation of the enzymes responsible for the attachment of these modifiers to protein surfaces and their subsequent removal. I also have an active interest in the development of novel proteomics methods and mass spectrometry-based assays.
I studied Chemistry in Marburg, Germany and at the University of Birmingham graduating with a MSci degree in 2002. This was followed by doctoral studies in Oxford at the Department of Organic Chemistry working on the synthesis of glycoprotein mimics as biological probes. My postdoctoral research with Dr Benedikt Kessler at the Nuffield Department of Medicine,Oxford introduced me to the use of mass spectrometry and proteomics in the investigation of infectious diseases and post-translational protein modifications. In 2010 I moved to DPAG in order to take up the management and running of the OXION Proteomics facility. Currently I am also holding a Retained Lectureship in Biochemistry at Pembroke College.
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
Scotti JS. et al, (2014), Proc Natl Acad Sci U S A, 111, 13331 - 13336
Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.
Kar P. et al, (2014), Curr Biol, 24, 1361 - 1368
Spatiotemporal Transitions in Cardiac Neuronal Co-Cultures
Burton RAB. et al, (2014), BIOPHYSICAL JOURNAL, 106, 630A - 630A
Changes in gene expression associated with FTO overexpression in mice.
Merkestein M. et al, (2014), PLoS One, 9
Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes.
McGouran JF. et al, (2013), Chem Biol, 20, 1447 - 1455