Wellcome Trust Oxion Proteomics Core Facilities Scientist
I am interested in the application of proteomics, chemical biology and mass spectrometry to the investigation of cell physiology. In particular my research interests focus on cellular ubiquitination and other regulatory post-translational modifications. This includes detailed characterisation of the enzymes responsible for the attachment of these modifiers to protein surfaces and their subsequent removal. I also have an active interest in the development of novel proteomics methods and mass spectrometry-based assays.
I studied Chemistry in Marburg, Germany and at the University of Birmingham graduating with a MSci degree in 2002. This was followed by doctoral studies in Oxford at the Department of Organic Chemistry working on the synthesis of glycoprotein mimics as biological probes. My postdoctoral research with Dr Benedikt Kessler at the Nuffield Department of Medicine,Oxford introduced me to the use of mass spectrometry and proteomics in the investigation of infectious diseases and post-translational protein modifications. In 2010 I moved to DPAG in order to take up the management and running of the OXION Proteomics facility. Currently I am also holding a Retained Lectureship in Biochemistry at Pembroke College.
Natural Product Inhibitors of Ubiquitin Conjugation and Deconjugation
Hess W. et al, (2016), Studies in Natural Products Chemistry Bioactive Natural Products
Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein.
Behrens AJ. et al, (2016), Cell Rep, 14, 2695 - 2706
Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.
Tarhonskaya H. et al, (2015), J Biol Chem, 290, 19726 - 19742
The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated.
Jallow S. et al, (2015), Eur J Immunol, 45, 2232 - 2242
Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization.
Pettingill P. et al, (2015), Neurology, 84, 1233 - 1241