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Heather Booth


Postgraduate Student

Research Summary

Mutations in Leucine-rich repeat kinase protein 2 (LRRK2) are the most common known cause of familial Parkinson’s Disease (PD) and cause a disease phenotype similar to that found in patients with the sporadic disease. I am studying the phenotypes of dopaminergic neurons that have been differentiated from patient-derived induced pluripotent stem cells in order to understand the dysfunction that can arise from LRRK2 mutations. Further to this I am using molecular techniques to uncover the pathways that LRRK2 is involved in, with the objective of understanding this protein’s role in both healthy and PD neurons.

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