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Harry Clifford

Postgraduate Student

DPhil Physiology, Anatomy and Genetics

The University of Oxford

Research Summary


I am broadly interested in computational genomics, striving to extract biological information from large genomic datasets. At Oxford my research focusses on the application of computational and statistical methods to high-throughput RNA sequencing data. This has ranged from differential expression, to co-expression network and clustering analyses, seeking to gain insight into the biological processes underlying many different diseases and disorders, including influenza and autism.


Before joining the Ponting Group in 2012, I studied at the University of Nottingham reading for an MSci in Human Genetics. My undergraduate dissertation was centred around bioinformatics, and focussed on pattern-searching DNA for transcription factor binding sites using a Hidden Markov Model. I later gained a Genetics Society summer studentship for bioinformatic analysis of genome-wide data, and spent this time investigating the effect of anti-epileptic drugs on fetal DNA methylation. Similarly my masters thesis focussed on genome-wide data, detecting signatures of positive selection in cattle by applying various statistics through a sliding window algorithm. I also worked for the University of Nottingham as a bioinformatics intern, comparing microarray data from cancers in humans and dogs.