Research groups
Goran Mohammad
PhD in Biomedical Science
Postdoctoral Research Scientist
I completed my PhD in Biomedical Science at University College London in 2016 under the supervision of Professor Stephen Pereira and Dr Dipok Dhar, where I investigated the role of metabolic enzymes in progression and development of pancreatic cancer, specifically I studied the pyruvate kinase M2 and Lactate dehydrogenase A enzymes as a diagnostic marker and therapeutic target for pancreatic cancer.
After PhD graduation, I joined prof. Lakhal-Littleton’s group at department of Physiology, Anatomy & Genetics, University of Oxford, as a Postdoctoral Research Assistant. Projects of our group focus on the role of hepcidin and ferroportin in the intracellular and extracellular iron homeostasis, and its effect on the human health. I am currently focusing on the study of the role of hepcidin/ferropertin axis in iron regulation in the heart (cardiovascular system), the kidney, the placenta and the vasculature, by utilising novel animal models of tissue-specific alterations in iron metabolism.
Recent publications
-
The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload.
Journal article
Mohammad G. et al, (2021), Kidney Int, 100, 559 - 569
-
Fetal liver hepcidin secures iron stores in utero.
Journal article
Kämmerer L. et al, (2020), Blood, 136, 1549 - 1557
-
Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer
Journal article
MOHAMMAD G. et al, (2019), Cancers
-
Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice.
Journal article
Lakhal-Littleton S. et al, (2019), Proc Natl Acad Sci U S A, 116, 13122 - 13130
-
Ex Vivo PD-L1/PD-1 Pathway Blockade Reverses Dysfunction of Circulating CEA-Specific T Cells in Pancreatic Cancer Patients.
Journal article
Chen Y. et al, (2017), Clin Cancer Res, 23, 6178 - 6189