Long non coding RNAs are class of newly discovered genes that have an important biological functions and roles in human diseases. Many lncRNA’s are expressed in the brain and play a regulatory role in neurogenesis, however the in vivo role and the molecular mechanisms that they are playing are still not clear. Paupar, Pax6 upstream paired box 6, is a vertebrate conserved lncRNA that is expressed in the brain, and regulates cell self-renewal and differentiation in neuroblastoma cell line by binding to transcription regulators proteins genome wide. In my DPhil project, I show that Paupar is expressed in the subventricular zone, which is the site of postnatal stem cell niche, and regulate the expression of genes important for neural proliferation and differentiation. I also show that Paupar is important for regulating neurogenesis and the maintenance of stem cells in vivo. I am working to provide more understanding about the role of the lncRNA Paupar in the CNS biology.
I am a second year DPhil student at DPAG, I obtained my master’s degree in Molecular biology from University of Southern California and my bachelor’s degree from King Saud University in Riyadh, Saudi Arabia.