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- Wade-Martins Group Research Group
Human induced-pluripotent stem cell (hiPSC) technology has enabled the study of adult cortical neurons from healthy individuals and Alzheimer’s disease (AD) patients. Synaptic dysfunction has been widely demonstrated in AD animal models and commonly manifests as alterations in long-term plasticity. My project focuses on the use of patient iPSC-derived cortical neurons harbouring familial AD mutations to investigate synaptic phenotypes using electrophysiological, optogenetic and molecular approaches. An important question I want to investigate is whether familial AD mutations in different genes converge upon common changes in synaptic transmission and plasticity.