Emma N. Bardsley
Postgraduate DPhil Student
Hypertension is central in determining cardiovascular risk and is a potent indicator of morbidity and mortality; however, there is an unmet clinical need for disease-modifying and prophylactic interventions. Our research group addresses this by investigating the processes that modulate sympathetic activity and my research aims to identify novel targets within the cardiac-sympathetic ganglia, that may translate from bench to bedside.
Dysautonomia is a well-established contributor to the development and progression of clinical hypertension and many other cardiovascular diseases. Sympathetic hyperactivity and vagal impairment are features of human hypertension as well as in subjects with a familial predisposition for hypertension. This neural phenotype is highly conserved and also observed in the spontaneously hypertensive rat (SHR) as well as young prehypertensive SHR (preSHR).
My research aims to understand the key processes involved in sympathetic hyperactivity and the molecular mechanisms that impair sympathetic-cardiac communication. The primary goal is to establish how these processes are altered in cardiac disease, to identify novel targets for the future development of effective clinical anti-hypertensive treatments.
Bardsley EN, Davis H, Olujimi A, Buckler KJ, Shivkumar K, Ardell JL, Paterson DJ. RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia During Cardiac Sympathetic Hyperactivity. Sci. Reports, 2018;8(1):1-13 doi:10.1038/s41598-018-26651-7.
Bardsley EN, Davis H, Buckler KJ Paterson DJ. Neurotransmitter Switching Coupled to Beta-Adrenergic Signalling in Sympathetic Neurons in Prehypertensive States. Hypertension. 2018;71(6):1226-1238. doi:10.1161/HYPERTENSIONAHA.118.10844.
Larsen HE, Bardsley EN, Lefkimmiatis K, Paterson DJ. Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States. J. Neurosci. 2016; 36 (33):8562-8573. doi:10.1523/JNEUROSCI.1059-16.2016
Bardsley EN, Larsen HE, Paterson DJ. Impaired cAMP-cGMP cross-talk during cardiac sympathetic dysautonomia. Channels (Austin). 2016:1-3. doi:10.1080/19336950.2016.1259040
Davis H, Bardsley EN, Paterson DJ. Transcriptional profiling of stellate ganglia from normotensive and spontaneously hypertensive rat strains. Sci. Data, 2018 (in press)
Bardsley EN, Davis H, Buckler KJ, Paterson DJ. Neurotransmitter Switching in Sympathetic Neurons Coupled to Beta-Adrenergic Signalling in Hypertensive States. The FASEB Journal. 2018;32(1_supplement):591.1-591.1. doi:10.1096/fasebj.2018.32.1_supplement.591.1.
Bardsley EN, Davis H, Olujimi A, Buckler KJ, Shivkumar K, Ardell JL, Paterson DJ. Identification of Novel mRNA Transcripts in the Sympathetic Stellate Ganglia using RNA Sequencing. The FASEB Journal. 2018;32(1_supplement):596.4-596.4. doi:10.1096/fasebj.2018.32.1_supplement.596.4.
Bardsley EN, Davis H, Bayles R, Habecker B, Paterson DJ. Stellate Transcriptomics Reveal Consistent Patterns of Gene Expression Across Species. The FASEB Journal. 2018;32(1_supplement):918.3-918.3. doi:10.1096/fasebj.2018.32.1_supplement.918.3.
Bardsley EN, Davis H, Paterson DJ. Do Beta Adrenergic Blockers Also Work via the Peripheral Sympathetic Nervous System? 2017 https://icongresso.itarget.com.br/useradm/anais/?clt=ips.2&lng=I
Bardsley E, Paterson DJ. Impaired Cyclic Nucleotide Signalling in Pre-Hypertensive Spontaneously Hypertensive Rats: A Dichotomy of Pathways? The FASEB Journal. 2016;30(1_supplement):1006.5-1006.5. doi:10.1096/fasebj.30.1_supplement.1006.5.