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David Thompson

DPhil Student

I am a DPhil student based at the MRC Harwell Institute, where I work in the ‘Mouse Models of Neurodegeneration’ group under the supervision of Dr Thomas Cunningham and Professor Elizabeth Fisher. 

I am interested in the genetics and pathological mechanisms of amyotrophic lateral sclerosis (ALS). Current treatment options for ALS are severely limited, with approved drugs only offering a modest prolongation of survival. The lack of effective treatments for ALS persists in spite of significant research progress in the field, reflecting the difficulties in translating ALS research findings into effective treatments for patients. Improved translation will require the generation of new models which more closely recapitulate human ALS. My research focuses on the development and characterisation of so-called ‘humanised’ mouse models of ALS, in the hope that these models will provide better insights into ALS pathogenesis.