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Cleidson Alves

Postdoctoral Research Scientist

In 2006, I graduated in Biological Sciences from Uniaraxá in the beautiful city of Araxá-MG, Brazil. During this time, my studies were focused on chromosomal alterations in human diseases. I then started my PhD in Molecular and Cell Biology at the Medical School of Ribeirão Preto - University of São Paulo - studying the role and mechanisms of molecular motors in melanoma progression. In parallel, I was also interested in tumour cell heterogeneity; especially the tumour stem cell (tumour initiating cells) and its regulation by long non-coding RNAs.

Following that I moved to Boston (2012) and worked at the Massachusetts General Hospital - Harvard Medical School. There, still focussing on tumour cell heterogeneity, I studied the molecular pathways that drive cell dormancy. We described a new transient cell state in tumour carcinoma cells, called G0-like cells, and an entirely new molecular pathway that drives cells into the G0-like state.

I started work in the Goberdhan group in 2015 to initiate work on a new Cancer Research UK Programme grant investigating the role of the environmental stress sensor mTORC1 in controlling a poorly understood form of communication between cells involving exosomes (nanovesicles that can carry a mixture of proteins and RNAs). They have been implicated in promoting cancer progression through pre-metastatic niche formation and angiogenesis. A key aspect of my role will be to develop further collaborative interactions with the research groups of Adrian Harris (WIMM, Oxford) and Clive Wilson (DPAG, Oxford).

Recent publications:

AKT Inhibition Promotes Non-autonomous Cancer Cell Survival. (2015) Salony, Sole X, Alves CP, Dey-Guha I, Ritsma L, Boukhali M, Lee JH, Chowdhury J, Ross KN, Hass W, Vasudevan S, Ramaswamy S. Mol Cancer Ther. In press.

Liposomes of Chloroaluminium Phthalocyanine as a potential system for melanoma treatment by photodynamic therapy: photophysical, photochemical and in vitro biological assays (2015) Paula A. Barbugli, Cleidson P. Alves, Enilza M. Espreafico, Antonio C. Tedesco. Nanomedicine, Exp Dermato Volume 24, Issue 12, pages 970–972.

A Mechanism for Asymmetric Cell Division Resulting in Proliferative Asynchronicity (2015) Dey-Guha I*, Alves CP*, Yeh AC, Salony, Sole X, Darp R, Ramaswamy S. Mol Cancer Res. 2015 Feb;13(2):223-30. *contributed equally to this paper 

The lincRNA Hotair is required for epithelial-to-mesenchymal transition and stemness maintenance of cancer cell lines (2013). Alves CP, Fonseca AS, Muys BR, de Barros E Lima Bueno R, Burger MC, de Souza JE, Valente V, Zago MA, Silva WA Jr. Stem Cells. 2013 Dec; 31(12):2827-32.

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Recent publications