- Mann Group Research Group
My research interests focus on how Up/Down states modulate plasticity in the cortex. During slow wave sleep, cortical neurons alternate their activity between depolarised Up states and more hyperpolarised, silent Down states. This activity is synchronised across neurons, giving rise to characteristic slow oscillations. Up/Down states have been implicated in synaptic plasticity during sleep-associated memory consolidation. In my DPhil project, I aim to characterise plasticity mechanisms associated with Up/Down state activity in the mouse barrel cortex using electrophysiological methods both in vitro and in vivo.
I graduated from the University of Vienna in 2012 with a degree in Molecular Biology. In my final year, I undertook an extended research project in cellular neuroscience in Prof David Attwell’s lab at University College London. Following this, I joined the OXION Ion Channels and Disease Initiative as a DPhil student within the 4-year programme funded by the Wellcome Trust. After my rotation projects with Prof Maike Glitsch and Prof Ed Mann, I joined Prof Ed Mann’s lab in 2013 for my main DPhil project.
Extracellular acidosis impairs P2Y receptor-mediated Ca<sup>2+</sup> signalling and migration of microglia
Langfelder A. et al, (2015), Cell Calcium, 57, 247 - 256