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Adrian Soto Mota
MD
DPhil Student
My line of research focuses on ketone bodies metabolism.
Ketone bodies are fat-derived molecules that are produced in the liver when we fast. They act both as a source of energy and as a message for some organs to adapt their fuel management.
One of my supervisors (Professor Kieran Clarke) developed a ketone drink which, for the very first time, allows us to quickly and safely induce ketone blood levels like the ones observed after many days of fasting or following a strict ketogenic diet.
Since many diseases are characterised or worsened by fuel management impairments, this breakthrough opened a myriad of potential clinical applications. I am particularly interested in the potential benefits for diabetes mellitus patients.
Recent publications
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Why a d-β-hydroxybutyrate monoester?
Journal article
Soto-Mota A. et al, (2020), Biochemical Society transactions, 48, 51 - 59
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Safety and tolerability of sustained exogenous ketosis using ketone monoester drinks for 28 days in healthy adults.
Journal article
Soto-Mota A. et al, (2019), Regul Toxicol Pharmacol, 109