Adam Handel

• Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain.

  Handel AE. et al, (2017), Hum Mol Genet, 26, 79 - 89

• Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.

  Žuklys S. et al, (2016), Nat Immunol, 17, 1206 - 1215

• Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics.

  Handel AE. et al, (2016), Hum Mol Genet, 25, 989 - 1000

• Bioinformatics Analysis of Estrogen-Responsive Genes.

  Handel AE., (2016), Methods Mol Biol, 1366, 29 - 39

• EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy.

  Ricigliano VA. et al, (2015), PLoS One, 10

• National survey of UK medical students on the perception of neurology.

  Pakpoor J. et al, (2014), BMC Med Educ, 14

• DNase hypersensitive sites and association with multiple sclerosis.

  Disanto G. et al, (2014), Hum Mol Genet, 23, 942 - 948

• Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression.

  Handel AE. et al, (2013), BMC Med Genomics, 6

• Vitamin D supplementation and antibodies against the Epstein-Barr virus in multiple sclerosis patients.

  Disanto G. et al, (2013), Mult Scler, 19, 1679 - 1680

• Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease.

  Handel AE. et al, (2013), BMC Med, 11

• Next-generation sequencing in understanding complex neurological disease.

  Handel AE. et al, (2013), Expert Rev Neurother, 13, 215 - 227

• High reprint orders in medical journals and pharmaceutical industry funding: case-control study.

  Handel AE. et al, (2012), BMJ (Clinical research ed.), 344

• High reprint orders in medical journals and pharmaceutical industry funding: case-control study.

  Handel AE. et al, (2012), BMJ, 344

• Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.

  Babron MC. et al, (2012), Eur J Hum Genet, 20, 321 - 325

• Determination of the real effect of genes identified in GWAS: The example of IL2RA in multiple sclerosis

  Babron MC. et al, (2012), European Journal of Human Genetics, 20, 321 - 325

• Weekend admissions as an independent predictor of mortality: an analysis of Scottish hospital admissions.

  Handel AE. et al, (2012), BMJ Open, 2

• Vitamin D and multiple sclerosis: an interaction between genes and environment.

  Handel AE. and Ramagopalan SV., (2012), Mult Scler, 18, 2 - 4

• Meta-analysis of the relationship between multiple sclerosis and migraine.

  Pakpoor J. et al, (2012), PLoS One, 7

• Concealed effects of gene-environment interactions in genome-wide association.

  Handel AE. et al, (2012), Mult Scler Relat Disord, 1, 39 - 42

• Vitamin D and multiple sclerosis hospital admissions in Scotland.

  Disanto G. et al, (2011), QJM, 104, 1001 - 1003

• Of mice and men: experimental autoimmune encephalitis and multiple sclerosis.

  Handel AE. et al, (2011), Eur J Clin Invest, 41, 1254 - 1258

• SIAE rare variants in multiple sclerosis

  Handel AE. et al, (2011), MULTIPLE SCLEROSIS JOURNAL, 17, S522 - S522

• Seasonality of admissions with multiple sclerosis in Scotland.

  Handel AE. et al, (2011), Eur J Neurol, 18, 1109 - 1111

• Inequities in advice on vitamin D?

  Handel AE. et al, (2011), QJM, 104, 547 - 549

• Season of birth and anorexia nervosa.

  Disanto G. et al, (2011), Br J Psychiatry, 198, 404 - 405

• Relationship of UV exposure to prevalence of multiple sclerosis in England.

  Ramagopalan SV. et al, (2011), Neurology, 76, 1410 - 1414

• Comment on "Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice".

  Disanto G. et al, (2011), J Immunol, 186, 3803 - 3804

• Revisiting the T-cell receptor alpha/delta locus and possible associations with multiple sclerosis.

  Watson CT. et al, (2011), Genes Immun, 12, 59 - 66

• HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.

  Disanto G. et al, (2011), Neurology, 76, 781 - 786

• Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC).

  Burrell AM. et al, (2011), Discov Med, 11, 187 - 196

• The epidemiology of multiple sclerosis in Scotland: inferences from hospital admissions.

  Handel AE. et al, (2011), PLoS One, 6

• Comment on "Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects".

  Handel AE. et al, (2011), J Immunol, 186

• Smoking and multiple sclerosis: an updated meta-analysis.

  Handel AE. et al, (2011), PLoS One, 6

• Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study.

  Ramagopalan SV. et al, (2011), BMC Med, 9

• Smoking and multiple sclerosis: a matter of global importance.

  Handel AE. and Ramagopalan SV., (2011), Neuroepidemiology, 37, 243 - 244

• Haiti: the potential transgenerational effect of disasters.

  Handel AE. et al, (2011), QJM, 104, 69 - 71

• Estrogen-vitamin D interaction in multiple sclerosis.

  Disanto G. et al, (2011), Fertil Steril, 95

• Heterogeneity in multiple sclerosis: scratching the surface of a complex disease.

  Disanto G. et al, (2010), Autoimmune Dis, 2011

• Multiple sclerosis and risk of cancer: a meta-analysis.

  Handel AE. and Ramagopalan SV., (2010), J Neurol Neurosurg Psychiatry, 81, 1413 - 1414

• Visceral obesity and brain volume.

  Handel AE. et al, (2010), Ann Neurol, 68, 770 - 771

• The potential role of major histocompatibility complex class I in schizophrenia.

  Handel AE. and Ramagopalan SV., (2010), Biol Psychiatry, 68, e29 - e30

• A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.

  Ramagopalan SV. et al, (2010), Genome Res, 20, 1352 - 1360

• Tuberculosis and diabetes mellitus: is vitamin D the missing link?

  Handel AE. and Ramagopalan SV., (2010), Lancet Infect Dis, 10

• Genetic and environmental factors and the distribution of multiple sclerosis in Europe.

  Handel AE. et al, (2010), Eur J Neurol, 17, 1210 - 1214

• Contribution of genetic, epigenetic and transcriptomic differences to twin discordance in multiple sclerosis.

  Handunnetthi L. et al, (2010), Expert Rev Neurother, 10, 1379 - 1381

• An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis.

  Handel AE. et al, (2010), PLoS One, 5

• Association between maternal height and childhood outcomes.

  Handel AE. et al, (2010), JAMA, 304

• Multiple sclerosis and lung cancer: an unexpected inverse association.

  Handel AE. et al, (2010), QJM, 103, 625 - 626

• GPC5 and lung cancer in multiple sclerosis.

  Handel AE. and Ramagopalan SV., (2010), Lancet Oncol, 11

• Chronic cerebrospinal venous insufficiency and multiple sclerosis.

  Handel AE. et al, (2010), Ann Neurol, 68

• The questionable effectiveness of sunscreen.

  Handel AE. and Ramagopalan SV., (2010), Lancet, 376, 161 - 162

• No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.

  Handel AE. et al, (2010), J Neuroimmunol, 223, 120 - 123

• Is Lamarckian evolution relevant to medicine?

  Handel AE. and Ramagopalan SV., (2010), BMC Med Genet, 11

• The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

  Handel AE. et al, (2010), PLoS One, 5

• Environmental factors and their timing in adult-onset multiple sclerosis.

  Handel AE. et al, (2010), Nat Rev Neurol, 6, 156 - 166

• Epigenetics: molecular mechanisms and implications for disease.

  Handel AE. et al, (2010), Trends Mol Med, 16, 7 - 16

• Type 1 diabetes mellitus and multiple sclerosis: common etiological features.

  Handel AE. et al, (2009), Nat Rev Endocrinol, 5, 655 - 664

• Public health implications of epigenetics.

  Handel AE. and Ramagopalan SV., (2009), Genetics, 182, 1397 - 1398

• Has neurology been demystified?

  Handel AE. and Ramagopalan SV., (2009), Lancet, 373, 1763 - 1764

Recent Publications

• Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain.

  Handel AE. et al, (2017), Hum Mol Genet, 26, 79 - 89

• Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.

  Žuklys S. et al, (2016), Nat Immunol, 17, 1206 - 1215

• Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics.

  Handel AE. et al, (2016), Hum Mol Genet, 25, 989 - 1000

• Bioinformatics Analysis of Estrogen-Responsive Genes.

  Handel AE., (2016), Methods Mol Biol, 1366, 29 - 39

• EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy.

  Ricigliano VA. et al, (2015), PLoS One, 10