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You can find some of our current DPhil projects advertised below.

We play a leading role in the development of more efficient and cost-effective sequencing technologies © Male Drosophila accessory gland - Clive Wilson

Cardiac Science

Please check back soon.

CELL PHYSIOLOGY

Novel interactions of anaesthetics on oxygen sensitive TASK K+ channels derived from rat chemoreceptor cells

Prof K Buckler, Prof J Pandit

Application Deadline: No more applications being accepted

Fully funded 3-year National Institute of Academic Anaesthesia (NIAA) PhD studentship to investigate the novel interactions of anaesthetics on oxygen sensitive TASK K+ channels derived from rat chemoreceptor cells (carotid body).

 

Structure and function of key ABC Transporters in health and disease

Prof L Carpenter, A/Prof de Wet

Application Deadline: No more applications being accepted

Human ABC transporters are a family 52 integral membrane proteins that transport diverse molecules across cell membranes. Mutations in ABC transporters causes a range of diseases, including diabetes (ABCC8 and ABCC9), cystic fibrosis (ABCC7, CFTR) and blindness (ABCA4).

Development & cell biology

Defining the interplay between polycystin 1/2 signalling and cAMP signalling in different subcellular domains

Prof M Zaccolo

Application Deadline: No more applications being accepted

Primary cilia are ubiquitous organelles fundamental for vision, hearing, smell perception, breathing, excretion, reproduction and development and their disruption or loss leads to several diseases (ciliopathies).

metabolism & endocrinology

Please check back soon.

NEUROSCIENCE

Targeting TFEB to correct autophagy/lysosomal deficits in Parkinson’s disease 

Prof Richard Wade-Martins

Application Deadline: No more applications being accepted

Parkinson’s disease is the second most common neurodegenerative disorder but disease-modifying therapies are still lacking. Genetics and pathology strongly implicate lysosomal and autophagy dysfunction in Parkinson’s, making TFEB, a master-regulator of lysosomal biogenesis, an attractive target as a potential therapeutic. Importantly, activation or overexpression of TFEB prevents neurodegeneration and rescues Parkinson’s related autophagy/lysosome deficits. Despite increasing interest in this target, the pathways involved in TFEB function in Parkinson’s remain poorly understood, particularly in human neurons. This project will assess the effect of Parkinson’s mutations on TFEB activity and regulation to better understand the molecular pathways of neurodegenerative diseases.

 

Investigating the adaptive capabilities of the brain following asymmetric hearing loss

Prof Andrew King, Dr Fernando Nodal

Application Deadline: No more applications being accepted

This 3 year PhD project, which is funded by Action on Hearing Loss and the Wellcome Trust, will investigate the neural basis by which the brain is able to adapt to asymmetric hearing loss and extend this work to more natural listening conditions than those typically used in the laboratory. 

 

Effects of fasting-induced torpor on sleep and behaviour in mice

Prof V Vyazovskiy, Prof D Bannerman, Dr S Peirson

Application Deadline: No more applications being accepted

This project will investigate the effects of food restriction on torpor in mice, the effects of torpor on subsequent behavioural performance and sleep, and will develop a standardized approach to detect the occurrence of torpor during food restriction.